What condition is associated with a deficiency in cortisol and aldosterone?

A deficiency in both cortisol and aldosterone is characteristic of Addison’s disease, which is an adrenal insufficiency condition. In this disorder, the adrenal glands do not produce sufficient amounts of these critical hormones. Cortisol plays a crucial role in regulating metabolism, the immune response, and stress responses, while aldosterone is vital for maintaining electrolyte balance and blood pressure by regulating sodium and water levels in the body.

In Addison’s disease, the lack of these hormones leads to symptoms such as fatigue, muscle weakness, weight loss, hypotension, and changes in skin pigmentation. The deficiency can result from autoimmune destruction of the adrenal cortex or other causes, such as infections, that impair adrenal function. Given these details, it's clear why the condition linked to deficiencies in cortisol and aldosterone is Addison’s disease.